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信號(hào)通路
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生命科學(xué)
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有機(jī)化學(xué)
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無機(jī)化學(xué)
沒有相關(guān)數(shù)據(jù)
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材料科學(xué)
沒有相關(guān)數(shù)據(jù)
Tempo
Tempo 是一種經(jīng)典的一氧化氮自由基，也 是一種線粒體 ROS 的選擇性清除劑，可在催化循環(huán)中使超氧化物歧化。Tempo 可誘導(dǎo) DNA 鏈斷裂，并可用作將伯醇氧化為醛的有機(jī)催化劑。Tempo 具有誘變和抗氧化作用。
此產(chǎn)品僅用于科學(xué)研究，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)
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包裝價(jià)格促銷價(jià)數(shù)量
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100mg￥462.00370.00- +
- 貨號(hào): ajcx16766
- CAS: 2564-83-2
- 別名: 2,2,6,6-四甲基哌啶氧化物
- 分子式: C9H18NO
- 分子量: 156.25
- 純度: ＞98%
- 溶解度: DMSO: 100 mg/mL (583.84 mM)
- 儲(chǔ)存: Store at -20°C
- 庫存: 現(xiàn)貨
Background
Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].
[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.
