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- Methylprednisolone Sodium Succinate(6α-Methylprednisolone 21-hemisuccinate Sodium)
Methylprednisolone Sodium Succinate(6α-Methylprednisolone 21-hemisuccinate Sodium)
Methylprednisolone Sodium Succinate是一種糖皮質激素，是一種具有抗炎作用的免疫抑制劑。
此產品僅用于科學研究，我們不為任何個人用途提供產品和服務
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包裝價格促銷價數量
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10mg￥438.00350.00- +
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50mg￥688.00550.00- +
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100mg￥945.00756.00- +
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250mg￥1646.001316.00- +
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500mg￥2440.001952.00- +
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1g￥3388.002710.00- +
- 貨號: ajci4392
- CAS: 2375-3-3
- 別名: 6α-甲潑尼龍 21-半琥珀酸酯鈉鹽；甲基潑尼松龍琥珀酸鈉
- 分子式: C26H33NaO8
- 分子量: 496.53
- 純度: ＞98%
- 溶解度: DMSO : 116.67 mg/mL (234.97 mM; Need ultrasonic)； H2O : 50 mg/mL (100.70 mM; Need ultrasonic)
- 儲存: Store at -20°C
- 庫存: 現貨
Background
Methylprednisolone sodium succinate is the sodium succinate ester of methylprednisolone which a synthetic corticosteroid with anti-inflammatory and immunomodulating properties [1].
Methylprednisolone binds to specific nuclear receptors, altering gene expression and reducing proinflammatory cytokine production. Methylprednisolone also decreases the number of circulating lymphocytes, induces cell differentiation, and triggers apoptosis in sensitive tumor cell populations [1].
In human polymorphonuclear leukocytes, methylprednisolone sodium succinate exerted no effect on O2-· production, H2O2 production, or chemiluminescence at low concentrations (0.04 ~ 0.22 mM), but triggered significant inhibition at a high concentration of 2.7 mM [2]. In human neutrophils, methylprednisolone sodium succinate at a high concentration of 1 mg/ml inhibited chemotactic response [3].
In the National Acute Spinal Cord Injury Study, methylprednisolone sodium succinate (30 mg/kg bolus followed by 5.4 mg/kg/h infusion for 23 hours) showed no significant differences against the control group overall at 6 weeks. However, the recovery of motor score and sensory touch score at 6 weeks was slightly, but significantly greater in the methylprednisolone sodium succinate-treated group than the placebo group for those treated within 8 hours of injury [4].
References:
[1]. National Center for Biotechnology Information. PubChem Database. Methylprednisolone, CID=6741, https://pubchem.ncbi.nlm.nih.gov/compound/Methylprednisolone (accessed on July 20, 2020)
[2]. Levine P H, Hardin J C, Scoon K L, et al. Effect of corticosteroids on the production of superoxide and hydrogen peroxide and the appearance of chemiluminescence by phagocytosing polymorphonuclear leukocytes. Inflammation, 1981, 5(1): 19-27.
[3]. Majeski J A, Alexander J W. The steroid effect on the in vitro human neutrophil chemotactic response. Journal of Surgical Research, 1976, 21(4): 265-268.
[4]. Steeves J, Blight A. Chapter 24 - Spinal cord injury clinical trials translational process, review of past and proposed acute trials with reference to recommended trial guidelines. Handbook of Clinical Neurology, 2012, 109: 386-397.
