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- Angiotensin Receptor
- GAT228
GAT228
An allosteric agonist of the CB1 receptor
此產品僅用于科學研究，我們不為任何個人用途提供產品和服務
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包裝價格促銷價數量
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1mg￥575.00460.00- +
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5mg￥2012.001610.00- +
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10mg￥3725.002980.00- +
- 貨號: ajci71720
- CAS: 1446648-15-2
- 別名:
- 分子式: C22H18N2O2
- 分子量: 342.4
- 純度: ＞98%
- 溶解度: DMSO: 20 mg/ml
- 儲存: Store at -20°C
- 庫存: 現貨
Background
GAT228 is an allosteric agonist of cannabinoid receptor 1 (CB1), the R-(+)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT229 , and a component of the racemic mixture GAT211, which acts as both an agonist and PAM. GAT228 increases β-arrestin recruitment, cAMP inhibition, and ERK1/2 and PLCβ3 phosphorylation in HEK293A cells expressing GFP-tagged human CB1 (hCB1-GFP) in a concentration-dependent manner. Unlike GAT229, GAT228 has no effect on the binding of the CB receptor agonist CP 55,940 to membranes from CHO cells expressing hCB1 when used at concentrations up to 1 µM. It inhibits excitatory postsynaptic currents (EPSCs) in a subset of CB1-expressing murine autaptic hippocampal neurons when used at a concentration of 1 µM.
