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- Angiotensin-converting Enzyme (ACE)
- Utibapril (FPL 63547)
Utibapril (FPL 63547)
Utibapril (FPL 63547) 是一種具有抗高血壓活性的血管緊張素轉(zhuǎn)換酶 (ACE) 抑制劑。
此產(chǎn)品僅用于科學(xué)研究，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)
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包裝價(jià)格促銷價(jià)數(shù)量
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1mg￥6200.004960.00- +
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5mg￥12175.009740.00- +
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10mg￥20762.0016610.00- +
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20mg￥36562.0029250.00- +
- 貨號(hào): ajce49310
- CAS: 109683-61-6
- 別名: 烏替普利,FPL 63547
- 分子式: C22H31N3O5S
- 分子量: 449.56
- 純度: ＞98%
- 溶解度: Soluble in DMSO
- 儲(chǔ)存: Store at -20°C
- 庫存: 現(xiàn)貨
Background
Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.
Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].
[1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. [2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4.
