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Background

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis[2].

Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway[1].

丹參素是丹參的一種活性成分，通過激活 Nrf2 信號通路顯示出廣泛的心血管益處。

丹參素 (DSS) 顯著降低冠狀動脈流出物中標記酶（肌酸激酶和乳酸脫氫酶）的水平和心肌梗塞面積。這可能顯著有助于 I/R 損傷后心臟功能的恢復。 DSS 還具有 ROS 清除活性，并通過激活由 Akt 和 ERK1/ 2 在蛋白質印跡分析中[2]。

用單劑量丹參素對 tHcy 正常的大鼠進行急性治療不會改變血漿 tHcy。相反，丹參素顯著降低了 tHcy 升高的大鼠的 tHcy。丹參素治療后相對較高的半胱氨酸和谷胱甘肽水平表明其降低tHcy的作用是通過增加轉硫途徑的活性[1]。

[1]. YG Cao, et al. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol. 2009 Jun; 157(3): 482-490. [2]. Yu J, et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int J Clin Exp Med. 2015 Sep 15;8(9):14793-804.

Protocol

Animal experiment:

All chemicals are dissolved in saline, except for tolcapone which is dissolved in saline containing 20% (v/v) PEG 200. During experiments, rats are fasted overnight and randomLy assigned into different groups. About 200 μL blood is taken from orbital sinus alternatively after ethyl ether anaesthesia, and then the eye is quickly sterilized with alcohol and pressed with cotton. Blood samples are immediately collected into a polypropylene tube containing heparin-Na and centrifuged at 5000?g?at 5°C for 3 min. Prepared plasma samples are kept at ?20°C and analysed within 48 h.

參考文獻:

[1]. YG Cao, et al. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol. 2009 Jun; 157(3): 482–490.
[2]. Yu J, et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int J Clin Exp Med. 2015 Sep 15;8(9):14793-804.