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- Gap Junction Protein
- Danegaptide Hydrochloride
Danegaptide Hydrochloride
Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一種有效的、選擇性的和口服活性的間隙連接調(diào)節(jié)劑，具有抗心律失常作用。
此產(chǎn)品僅用于科學(xué)研究，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)
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包裝價(jià)格促銷價(jià)數(shù)量
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2mg￥1000.00800.00- +
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5mg￥1625.001300.00- +
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10mg￥2725.002180.00- +
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50mg￥8100.006480.00- +
- 貨號(hào): ajce55856
- CAS: 943133-81-1
- 別名: (4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸鹽酸鹽,GAP-134 Hydrochloride; ZP 1609 Hydrochloride
- 分子式: C14H18ClN3O4
- 分子量: 327.76
- 純度: ＞98%
- 溶解度: Water: ≥ 75 mg/mL (228.83 mM); DMSO: ≥ 55 mg/mL (167.81 mM)
- 儲(chǔ)存: Store at -20°C
- 庫(kù)存: 現(xiàn)貨
Background
Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein. Gap junction.
[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554
