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Brevilin A
A sesquiterpene lactone with anticancer activity
Isorhapontigenin
Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
CZC-25146
A potent LRRK2 inhibitor
GNE-9605
OSU-T315
OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
QX77
An activator of chaperone-mediated autophagy
Pennogenin 3-O-beta-chacotrioside
Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
EN6
An activator of autophagy
Lys01 trihydrochloride
An inhibitor of autophagy
NSC 185058
An inhibitor of ATG4B
PF-06447475
PF-06447475 是一種高效、選擇性和腦滲透性 LRRK2 抑制劑,IC50 為 3 nM。
GNE0877
A selective LRRK2 inhibitor
MLi-2
An LRRK2 inhibitor
Glycycoumarin
Glycycoumarin 是一種甘草中主要的生物活性香豆素。Glycycoumarin 通過(guò)激活自噬,抑制內(nèi)質(zhì)網(wǎng)應(yīng)激介導(dǎo)的 JNK 和 GSK-3 介導(dǎo)的線粒體途徑,來(lái)抑制肝細(xì)胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 細(xì)胞源蛋白激酶發(fā)揮抗肝癌活性 。
JH-II-127
An inhibitor of wild-type and mutant forms of LRRK2
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