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Brevilin A
A sesquiterpene lactone with anticancer activity
Isorhapontigenin
Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
OSU-T315
OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
QX77
An activator of chaperone-mediated autophagy
Pennogenin 3-O-beta-chacotrioside
Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
EN6
An activator of autophagy
Lys01 trihydrochloride
An inhibitor of autophagy
NSC 185058
An inhibitor of ATG4B
Glycycoumarin
Glycycoumarin 是一種甘草中主要的生物活性香豆素。Glycycoumarin 通過激活自噬,抑制內(nèi)質(zhì)網(wǎng)應(yīng)激介導(dǎo)的 JNK 和 GSK-3 介導(dǎo)的線粒體途徑,來抑制肝細(xì)胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 細(xì)胞源蛋白激酶發(fā)揮抗肝癌活性 。
Daurisoline ((R,R)-Daurisoline)
An alkaloid with diverse biological activities
3'-Hydroxypterostilbene
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue,
Actein
Actein 是從 Cimicifuga foetida 的根莖中分離的三萜糖苷。Actein 通過促進(jìn) ROS/JNK 活化和鈍化人膀胱癌中的 AKT 途徑來抑制細(xì)胞增殖,誘導(dǎo)自噬和凋亡。Actein 在體內(nèi)幾乎沒有毒性。
Soyasapogenol B
Soyasapogenol B,大豆的一種成分,具有抗增殖,抗轉(zhuǎn)移活性。Soyasapogenol B 觸發(fā)內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng),其介導(dǎo)結(jié)腸直腸癌中的細(xì)胞凋亡和自噬。
PIK-III
A selective inhibitor of Vps34
Licoricidin
Licoricidin (LCD) 從甘草 Glycyrrhiza uralensis Fisch 中分離,具有抗癌活性。Licoricidin (LCD) 通過誘導(dǎo)周期停滯,誘導(dǎo)細(xì)胞凋亡 (apoptosis) 和自噬 (autophagy),是一種對(duì)抗結(jié)直腸癌的潛在化學(xué)預(yù)防或化學(xué)治療劑。Licoricidin (LCD) 通過抑制腫瘤血管生成和淋巴管生成以及腫瘤組織局部微環(huán)境的變化抑制肺轉(zhuǎn)移。Licoricidin (LCD) 通過體外和體內(nèi) Akt 和 NF-κB 途徑的失活,增強(qiáng)吉西他濱誘導(dǎo)的骨肉
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