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Lazertinib
An irreversible inhibitor of mutant EGFRs
SU5408 (VEGFR2 Kinase Inhibitor I)
A potent, cell-permeable inhibitor of VEGFR2
Pelitinib (EKB-569)
An EGFR receptor tyrosine kinase inhibitor
AZD9291(Osimertinib)
An inhibitor of mutant EGFR
Erlotinib
An EGFR tyrosine kinase inhibitor
TAS6417
TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.
Afatinib dimaleate
An inhibitor of EGFR and ErbB2
ZM 323881 HCl
A potent and selective VEGFR2 inhibitor
BMS-599626 Hydrochloride
BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一種選擇性的口服生物可利用的 HER1 和 HER2 抑制劑,IC50 分別為 20 和 30 nM。 BMS-599626 Hydrochloride 對 HER4 (IC50=190 nM) 的效力降低約 8 倍,對 VEGFR2、c-Kit、Lck、MEK 的效力超過 100 倍。 BMS-599626 Hydrochloride 抑制腫瘤細胞增殖,并有可能增加腫瘤對放療的反應。
AV-412
A dual inhibitor of EGFR and HER2
RTC-5
RTC-5 是一種具有抗癌效力的優化吩噻嗪。RTC-5 顯示針對 EGFR 驅動的癌癥的異種移植模型的功效,其效果歸因于 PI3K-AKT 和 RAS-ERK 信號傳導的負調節。
PD168393
An irreversible EGFR kinase inhibitor
Dovitinib (TKI258) Lactate
A multi-kinase inhibitor
N-Desethyl Sunitinib
An active metabolite of sunitinib
Mutated EGFR-IN-1
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.
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