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Dodecanoylcarnitine
Dodecanoylcarnitine和脂肪酸氧化紊亂有關(guān),如長鏈酰基輔酶脫氫酶缺乏癥、肉毒棕櫚酰基轉(zhuǎn)移酶I/II缺乏癥,也和乳糜瀉有關(guān)。
RU-SKI 43 (hydrochloride)
An inhibitor of hedgehog acyltransferase
Oleyl Anilide
An ACAT inhibitor
TMP-153
A potent ACAT inhibitor
E-5324
E-5324是一個(gè)強(qiáng)效的酰基輔酶A:膽固醇酰基轉(zhuǎn)移酶(ACAT)抑制劑,其IC50值在44至190nM之間。
YM17E
YM17E是一種酰基輔酶a:膽固醇酰基轉(zhuǎn)移酶(ACAT)的抑制劑,在兔肝微粒體的體外實(shí)驗(yàn)中,IC50值為44nM。
PF-06471553
PF-06471553是一種有效的,選擇性的,可口服的monoacylglycerolacyltransferase3(MGAT3)抑制劑,IC50值為92nM。
RP-64477
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic
K-604 dihydrochloride
K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.
FCE 28654
FCE28654是一種水溶的酰基COA:膽固醇酰基轉(zhuǎn)移酶(ACAT)抑制劑,在兔主動脈、腸和猴肝臟的微粒體中,抑制ACAT的活性,IC50值分別為2.55,1.08和5.69μM。
ABT-046
ABT-046 是一種具有口服活性的選擇性二酰基甘油酰基轉(zhuǎn)移酶 1 (DGAT-1) 抑制劑,IC50 為 8 nM。
DGAT-1 inhibitor
A DGAT-1 inhibitor
Diacylglycerol acyltransferase inhibitor-1
Diacylglycerolacyltransferaseinhibitor-1是一個(gè)二酰基甘油酰基轉(zhuǎn)移酶(DGAT1)抑制劑。
1-Oleoyl-2-hydroxy-sn-glycero-3-PC
A lysophospholipid
PF-06424439 methanesulfonate
PF-06424439是一種高效、口服生物可利用的選擇性二酰基甘油酰基轉(zhuǎn)移酶2(DGAT2)小分子抑制劑,IC50值為14nM。
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